Octet ® R4 Protein Analysis System
Highly Sensitive, Upgradeable System for Biomolecule Characterization

The Octet® R4 System Makes Biologics Development Affordable and Flexible

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Detection Technology
Bio-Layer Interferometry (BLI)
Biosensor Type
Disposable, single-use fiber optic biosensors with optional reuse by regeneration and/or re-racking in the biosensor tray
Data Presentation
Graphs displaying real-time kinetic binding sensorgrams, fitted result plots, and residuals of fits
Concentration data analysis including calibration curves and output of tabulated concentration data
Tabulated kinetic data
Epitope binning and cross-blocking matrices and trace overlays

Sample Type
Proteins, antibodies, peptides, DNA, RNA, liposomes, viruses and VLPs in various media including serum, buffers containing DMSO, periplasmic fractions, untreated cell culture supernatants, and crude cell lysates
Number of Spectrometers
Maximum Simultaneous Reads
Data Collection Rate
2, 5 or 10 Hz
Sample Position and Format
1 standard 96-well, black, flat-bottom microplate
Sample Volume
180–220 µL/well
Nondestructive testing

Orbital Flow Capacity
Static or 100–1500 rpm
Analysis Temperature Range
15°C to 40°C, in 1°C increments
Quantitation and Kinetics
Up to 4 assays in parallel
Molecular Weight Detection
>150 Da
Analysis Time per Sample
Real-time kinetic binding experiments from 5 minutes to 4 hours
Association Rate Constant (ka)
101 to 107 M-1 s-1
Dissociation Rate Constant (kd)
10-6 – 0.1 s-1
Affinity Constant (KD)
1 mM – 10 pM
Baseline Noise (RMS)
<3.0 pm
Baseline Drift
≤ 0.12 nm/hour
Quantitation Precision
CV <10%
72 kb (32.7 Kg)
Dimensions (H X W X D)
19.5 in X 22 in X 18.2 in
(49 cm X 56 cm X 46 cm)

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